The effect of consolidation chemotherapy for LA-NSCLC patients receiving concurrent chemoradiotherapy
Yelda Varol, Berna Komurcuoglu, Ufuk Yilmaz, Esra Korkmaz Korkmaz Kirakli, Aysen Evkan
J Clin Anal Med 2017;8(2):142-146
Aim: The efficacy and safety of consolidation chemotherapy (CCT) following concurrent chemoradiotherapy are not adequately established for patients with locally advanced non-small-cell lung cancer (LA-NSCLC). In this context, the present study aims to evaluate the efficacy and toxicity of CCT.Material and Method: We retrospectively analyzed the overall survival (OS) and progression-free survival (PFS) of 83 LA-NSCLC patients treated with concurrent CRT as an initial treatment with (n:20) or without CCT (n:63). All patients were cytohistologically proven to have NSCLC and diagnosed with clinical Stage III (n:48 for IIIA and n:35 for IIIB) according to the staging system published by the American Joint Committee on Cancer (AJCC) in 2009. All patients received curative thoracic radiotherapy with concurrent platinum doublet chemotherapy. Results: The mean age of the lung cancer patients was 59 (±7.3); 89.2% were male (n:74),and there were only 9 female patients (10.8%).When we compared the outcome of LA-NSCLC patients treated with CCT (median 10.4 months) to the patients treated without CCT (median 13.8 months), the log-rank analysis demonstrated a statistically significant difference for an inferior progression-free survival (p=0.046) in patients receiving CCT. However, no significant association was observed for overall survival (17.4, 21 months, respectively) (p>0.05). Patients with CCT presented higher levels of hematological side effects compared with the patients without CCT (p<0.001). Discussion: The present study showed that consolidation chemotherapy (CCT) following concurrent chemoradiotherapy did not prolong the overall survival but caused higher levels of chemotherapy-related hematological toxicity in the case of LA-NSCLC.
Non small cell lung cancer, Concurrent chemoradiotherapy, Consolidation chemotherapy,
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Yelda Varol, Berna Komurcuoglu, Ufuk Yilmaz, Esra Korkmaz Korkmaz Kirakli, Aysen Evkan, The effect of consolidation chemotherapy for LA-NSCLC patients receiving concurrent chemoradiotherapy , J Clin Anal Med 2017;8.(2):142-146