Aim: Hallux valgus is the deformity of the first metatarsophalangeal (MTP) joint with abduction and valgus rotation of the great toe, combined with a medially prominent first metatarsal head. Hyaluronic acid injection has been used in the treatment of degenerative disorders of several joints successfully. In this research, it was aimed to investigate the effectiveness of hyaluronic acid injection in patients with hallux valgus.Material and Methods: Eleven female and two male patients with hallux valgus were included in this pilot study. Patients with mild and moderate hallux valgus were included in the study. 1 cc hyaluronic acid was injected into the affected MTF joint 3 times at one week intervals. Visual analogue scale(VAS) score, walking time without pain, walking distance and daily analgesic needs of the patients were recorded. All clinical outcomes were assessed before, and one and three months after the first injection prospectively.Results: The mean VAS score was 83.08±4.58. One month after the first injection, VAS scores of patients were found to be decreased significantly (30±4.38, P:0.001). Also increased walking time and distance and decreased daily analgesic need were observed in the first month of postinjection follow-up (P:0.001). After 3 months, the positive outcomes remained significant compared to preinjection evaluations.Discussion: According to our preliminary results, we suggest that hyaluronic acid injection may be effective in reducing pain and increasing walking time and distance in patients with hallux valgus. Future studies are needed to clarify the beneficial effects of hyaluronic acid injection in patients with hallux valgus.