Low Prognostic Nutritional Index Before Radiotherapy is a Poor Prognostic Factor for Rectum Cancer
Neslihan Kurtul, Celalettin - Erošlu
J Clin Anal Med 2017;8(3):185-189
Aim: The aim of this study was to examine the effect of the prognostic nutritional index (PNI) value on survival in patients with rectum cancer who received postoperative chemoradiotherapy. Material and Method: The study included 65 patients who received adjuvant chemoradiotherapy. Radiotherapy of 5040 cGy and simultaneous 5-FUFA chemotherapy was given to the patients. The patients were divided into two groups as PNI %u226446 and PNI >46 according to the ROC analysis. The differences in survival between the groups were calculated using the log rank test. The univariate and multivariate hazard ratios were calculated using the Cox proportional hazard model.Results: The patients included 22 (33.8%) females and 43 (66.2%) males. The low PNI group comprised 28 (43.1%) patients and the high PNI group, 37 (56.9%). According to the Kaplan-Meier analysis, mean survival was 59 months (95% CI; range, 44.95-73.08 months) in the low PNI group and 80 months (95% CI; range 66.53- 94.82 months) in the high PNI group. The 5-year survival rate was 49% in the low PNI group and 65% in the high PNI group. In the univariate analysis, T stage, N stage, tumor diameter, and PNI had an effect on overall survival (p<0.05). In the multivariate Cox regression analysis, T stage (p=0.014), tumor diameter (p=0.023), and PNI (p=0.045) were found to be prognostic factors affecting overall survival, independent of the other variables. Discussion: The results of the study showed that the PNI value before radiotherapy is a poor prognostic factor for rectum cancer.
Prognostic nutritional index, Radiotherapy, Rectum cancer,
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How to Cite :
Neslihan Kurtul, Celalettin - Erošlu, Low Prognostic Nutritional Index Before Radiotherapy is a Poor Prognostic Factor for Rectum Cancer, J Clin Anal Med 2017;8.(3):185-189