Aim: Neutrophil-to-lymphocyte ratio (NLR) is an easily measurable biomarker from complete blood count. NLR has been investigated previously as a potential predictor of survival rates in various types of cancers. However, there are limited number of studies performed regarding usefulness of NLR predicting mortality in patients with sepsis. Our aim in this study was to evaluate the association between NLR and mortality of the patients with sepsis in intensive care unit (ICU).Material and methods: The patients followed up with the diagnosis of sepsis in internal medicine ICU of our hospital between September 1st, 2014 and December 31st, 2015 were assessed retrospectively. Demographic, clinical, and laboratory data were obtained from the patients' medical records.Results: A total 104 patients were included in the study. ICU mortality was 57.7% in patients with sepsis. When survivors and non-survivors in ICU were assessed regarding neutrophil counts, lymphocyte counts and NLR, no statistically significant difference was determined (p>0.05). While mortality rate in ICU increased with increasing quartile of NLR, no significant difference was determined in ICU mortality (all p>0.05). Also, there was no relationship with NLR and hospital mortality and 6-months mortality in patients with sepsis (p>0.05).Discussion: No significant correlation was found between NLR and mortality rate in ICU and long-term mortality in patients with sepsis.