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Abstract

Ýs alexithymia associated with high disease activity in rheumatoid arthritis?


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Authors
SENIZ - AKCAY YALBUZDAG, ILKER - SENGUL, DURSUN HAKAN DELIBAS, TACISER - KAYA, ALTINAY - GOKSEL KARATEPE

J Clin Anal Med 2017;8(5):-
doi:10.4328/JCAM.4900

Abstract
Aim: To investigate the association between alexithymia and disease activity in patients with rheumatoid arthritis. Material and Method: A total of 97 female patients diagnosed with RA were enrolled in the study. First, the patients were classified into two groups as alexithymics and non-alexithymics according to the Toronto Alexithymia Scale-20 (TAS-20) threshold score of 61. Subsequently, non-alexithymic patients were divided into three groups according to tertile values as high-normal, middle-normal, and low-normal. Disease activity was determined by the Disease Activity Index with 28 joints using erythrocyte sedimentation rate (DAS28-ESR). To understand the contribution of patient-reported components to DAS28-ESR, a DAS28-ESR-derived index called DAS28-P [Disease Activity Score in 28 joints attributable to Patient-reported Components (tender joint count and patient global assessment of disease activity)] was used. The DAS28-P index was calculated as the ratio of the fraction of the total DAS28-ESR score contributed by the tender joint count and patient global assessment of disease activity score to total the DAS28-ESR score. Differences across TAS-20 score groups for DAS28-ESR and for DAS28-P were studied. Results: Twenty-eight of 97 patients (28.8%) were classified as alexithymic. The mean DAS28-ESR score was significantly higher in the alexithymic group than in the low-normal TAS-20 score group (p=0.004). The median DAS28-P score was significantly higher in the alexithymic group than in the low-normal and middle-normal TAS-20 score groups (p=0.001, p=0.015, respectively). The median DAS28-P score was also significantly higher in the high-normal TAS-20 score group than in the low-normal TAS-20 score group (p=0.047). Discussion: In patients with high disease activity, the presence of alexithymia may be a confounding factor.

Keywords : Alexithymia, Disease activity, Rheumatoid arthritis,

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How to Cite :
SENIZ - AKCAY YALBUZDAG, ILKER - SENGUL, DURSUN HAKAN DELIBAS, TACISER - KAYA, ALTINAY - GOKSEL KARATEPE, Ýs alexithymia associated with high disease activity in rheumatoid arthritis? , J Clin Anal Med 2017;8.(5):-