Aim: Thromboelastometry shows the monitorization of the hemostasis axis with the use of a single method instead of conventional techniques.Material and Method: This study was conducted on 50 patients who were admitted to the intensive care unit and diagnosed with sepsis together with 50 healthy volunteers from the local population. The patients were divided into two groups. Group S consisted of patients who were diagnosed with sepsis in the intensive care unit. Group C consisted of healthy volunteers who were selected from the local population and had no impairments of their coagulation profile. Thromboelastometry measurements were performed for both groups.Results: While elongation was observed in PT and aPTT between Group C and Group S, a decrease was observed in platelet counts (p<0.05). When analyzing thromboelastometry parameters, significant differences were seen between groups (p<0.05) in all parameters in INTEM and all parameters except CT in EXTEM. There was no significant differences in the CT parameter of the EXTEM measurement between groups (p>0.05). Within Group S, when the results from the time of diagnosis and the 24th hour were compared, no significant difference was observed in PT, aPTT, platelet count, or in all INTEM and EXTEM parameters examined.Discussion: Our results revealed that sepsis was clinically more disruptive of the intrinsic pathway. Thromboelastometry was a suitable technique for use in the diagnosis of sepsis, but did not show a significant effect in the follow-up of sepsis. We recommend using thromboelastometry for the diagnosis of sepsis.