About Us Online First Current Issue All Issues For Authors Search
Abstract

The effects of Silibinin on corporal oxidative stress and antioxidant enzymes in ischemic priapism


PDF
Authors
Faruk Küçükdurmaz, Erkan Efe, Yusuf Ergün, Metin Kılınç, Sefa Resim

J Clin Anal Med 2017;8(Suppl 4):-
doi:10.4328/JCAM.4977

Abstract

Aim: Ischemic priapism is characterised by progressive hypoxia,hypercapnia, and acidosis with subsequent corporal fibrosis which may lead to erectile dysfunction.In various studies, silibinin has been shown to have antiapoptotic,antilipidemic, and antioxidant activities in many organs.However,data is lacking about the effects of silibinin on penile tissues of prolonged priapism cases. The aim of the study was to investigate the possible protective effects of silibinin on oxidative stress and antioxidant enzyme levels in an animal model.Material and Method: Thirty male Wistar-Albino rats were divided into five groups as control,12-hours (h) of priapism+isotonic (PI),12-h priapism+silibinin (PS),24-h PI, and 24-h PS groups,respectively.Priapism was induced by vacuum device and a constrictor rubber band was placed at the base of the erect penis. The rats were fed by isotonic and silibinin with oral gavage for 7 days after corresponding duration of priapic episodes.Then,the rats were anesthesized and penectomies were performed to investigate levels of malondialdehyde (MDA),superoxide dismutase (SOD),glutathione peroxidase (GPx), and nitric oxide (NO) Results: Corporal MDA levels significantly increased as the duration of priapism prolonged.Administration of silibinin insignificantly decreased MDA levels in experimental groups.Corporal GPx and SOD levels were significantly higher in experimental groups than controls.However,increases in antioxidant enzymes were not significant between 12 and 24 hour vehicle groups.Administration of silibinin significantly reduced SOD and GPx levels in 12 and 24 hour priapism groups,respectively.Discussion: This study demonstrated that experimental priapism results in increased oxidative injury in corporal tissues and that treatment with silibinin alleviated those effects.Therefore,it can be extrapolated that silibinin may be used as an antioxidant agent in the treatment of ischemic priapism in future urology practice. 



Keywords : Silibinin, Priapism, Oxidative stress, Antioxidant enzymes,

Citations in Google Scholar

How to Cite :
Faruk Küçükdurmaz, Erkan Efe, Yusuf Ergün, Metin Kılınç, Sefa Resim, The effects of Silibinin on corporal oxidative stress and antioxidant enzymes in ischemic priapism, J Clin Anal Med 2017;8.(Suppl 4):-