The role of hematological and biochemical markers in preeclampsia prediction
Lebriz Hale Aktun, Nilay Karaca, Yaşam Kemal Akpak, Erol Arslan
J Clin Anal Med 2017;8(Suppl 4):306-309
Aim: To investigate whether complete blood count parameters of early pregnancy or biochemical markers of first-trimester trisomy screening were related to the prediction of early onset preeclampsia. Material and Method: Group 1 (n=214) was composed of patients between 18-40 years old with a single pregnancy who was diagnosed with preeclampsia at <34 gestational weeks and had delivery at %u226537 weeks of gestation. Group 2 (n=240) was a control. Women who became pregnant by assisted reproductive technologies or had a body mass index (BMI) >30kg/m2, had a history of delivery complicated by chromosomal anomalies, current or previous medical problems, or multiple pregnancies and patients who had vaginal bleeding in the antenatal period or a history of preterm delivery were excluded. Preeclampsia for pregnancy is defined as having a systolic blood pressure %u2265140 and diastolic blood pressure %u226590 as well proteinuria after the 20th gestational week. Blood samples for complete blood count, PAPP-A, and free beta-HCG were collected between 11 0 to 13 6 gestational weeks. Results: The mean gestational weeks at delivery and birth weight were significantly lower in Group 1 (preeclampsia) than in Group 2 (control). NRL and PDW were found significantly higher in Group 1. Lymphocyte count was significantly lower in Group 1. PAPP-A was lower in Group 1. Discussion: We found a strong relation between high levels of NLR and PDW, as well as low levels of lymphocyte count and PAPP-A, with early onset preeclampsia development during the current pregnancy.
Preeclampsia, Complet blood count, PAPP-A, Free- beta-HCG,
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Lebriz Hale Aktun, Nilay Karaca, Yaşam Kemal Akpak, Erol Arslan, The role of hematological and biochemical markers in preeclampsia prediction, J Clin Anal Med 2017;8.(Suppl 4):306-309