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Abstract

The effect of Oxaliplatin on heart tissue of the rats


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Authors
Ufuk Eryżlmaz, Saliha Aksun, Buket Demirci

J Clin Anal Med 2018;9(1):9-12
doi:10.4328/JCAM.5223

Abstract
Objective: This study investigates the cardiotoxicity of Oxaliplatin (OXA) on rat heart by using oxidative stress parameters on myocardium and troponin I and S100A1 levels of serum. Material and methods: Acute OXA treatment (4 mg/kg/ 1st, 3rd and 5th days) has been administered to the 6-8 months old rats. The heart and serum samples obtained at day 7th and 14th days of the study. Chronic OXA treatment (4 mg/kg/ two days of week/ 4 weeks) administered, sacrificed and heart and serum samples obtained at day 28th and following 21 days of the completing administration of drugs. Results: Oxa treatment did not cause heart injury in our acute and chronic study design. Conclusion: Oxa treatment seems safe.

Keywords : Cardio-oncology, Oxaliplatin, S100A1, Troponin I,

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How to Cite :
Ufuk Eryżlmaz, Saliha Aksun, Buket Demirci, The effect of Oxaliplatin on heart tissue of the rats, J Clin Anal Med 2018;9.(1):9-12