Aim: Lack of good marginal adaptation in dental restorations over time tends to dissolve the cement in the oral cavity, which leads to the accumulation of plaque, tooth decay, pulp contention, gingivitis, periodontal diseases and ultimately treatment failure. The aim of this study is to evaluate and compare the internal and marginal adaptation in metal-ceramic and all-ceramic restorations made by traditional and CAD/CAM methods. Material and Method: 1. Preparation of working cast and die 2. Preparation of restorations: In this study, the samples were divided into six groups of 10, which are as follow; Group A: metalceramic restorations without collar made by manual method (traditional and conventional). Group B: metal-ceramic restorations without a metal collar, in which the wax coping was made of special blanks by CAD/CAM method, and the rest of process is manual. Group C: metal-ceramic restorations without a metal collar, in which their frame was made by using dry milling method and Sintron technology and the rest of process was done manually. Group D: E.max-Press all-ceramic restorations (lithium disilicate). Group E: All-ceramic restoration with Core Zirconia prepared by CAD/CAM method and porcelain layering. Group F: Trans-Lucent zirconia (solid) all-ceramic restorations as full-contour by CAM/COD method. 3. Measuring the amount of the gap: Replica technique was used for this purpose. Results: The lowest mean gap in marginal and internal restorations was in group B, and the highest amount was in Group C and D, respectively, and altogether there was a significant diference between 6 study groups (P<0.001). The mean marginal gap in all groups (except group B) was more than 120 microns, which is not clinically acceptable. The best marginal and internal adaptation was observed in Group A and B. Discussion: Based on the findings of this study, traditional spruing technique, investment, wax removing and alloy injection still provide the best marginal adaptation, and in general comparison, metal-ceramic restorations are preferred over all-ceramic restorations.