Protective effects of aloe vera alcoholic extract gel on changes of ovarian hormones in experimental model of multiple sclerosis
Elham Rahmanian koshkaki , Hajar Haghshenas , Eghbal Sekhavati, Fatemeh Mohseni, Mina Tajali
J Clin Anal Med 2018;9(4):-
Aim: Multiple Sclerosis (MS) is a demyelinating autoimmune inflammatory disorder of central neural system associated with neural disability in childbearing age. Studies show that common medicines in the treatment of MS have side effects, especially on the reproduction system. This study was conducted to examine the protective effects of Aloe Vera alcoholic extract gel on changes of ovarian hormones in an experimental model of MS. Material and Method: In this experimental study, 30 female Wistar rat were randomly assigned to 6 groups (5 in each group). In 20 rat (4 groups) injections of 14 microliters of ethidium Bromide in the lateral ventricles of the brain were made. The 5 other rats were injected with 14 microliters of saline in the lateral ventricle of the brain, and the remaining 5 rats were considered control group. Then 3 groups of MS-induced rats were treated with the alcoholic extract of Aloe Vera gel in the dosage of 50 mg/kg, 100 mg/kg, and 200 mg/kg. Finally, all the rats were anesthetized deeply, and then for measuring the serum density of LH, FSH, estrogen and progesterone, blood was taken from their heart. Result: A meaningful increase in the density of LH and FSH hormones, and a meaningful decrease in the density of estrogen and progesterone in group 3 was observed compared with the control group. Also, the density of the progesterone in group 6 showed a meaningful increase compared to group 3. Discussion: This study demonstrates that with induction of MS, there will be a decrease in the density of estrogen and progesterone hormones and an increase in the density of gonadotropin hormones; and treatment with an extract of Aloe Vera gel has an improving effect on serum levels of sex hormones.
Aloe Vera, alcoholic extract, ovarian hormones, experimental model,
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Elham Rahmanian koshkaki , Hajar Haghshenas , Eghbal Sekhavati, Fatemeh Mohseni, Mina Tajali , Protective effects of aloe vera alcoholic extract gel on changes of ovarian hormones in experimental model of multiple sclerosis, J Clin Anal Med 2018;9.(4):-