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Abstract

Comparison of liquid based cytology cervical smears with histopathological findings


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Authors
Seyhan Ozakkoyunlu hascicek, Tuba Oğuzsoy, Kamile Gulcin Eken, Fevziye Kabukcuoglu

J Clin Anal Med 2018;9(5):359-362
doi:10.4328/JCAM.5763

Abstract

Objective: Cervical cancer is still a health problem in countries where cervical cancer screening is not routinely performed. An important decrease in the rate of mortality from cervical cancer has been observed after the usage of PAP test. Within the last decade liquid-based cytology (LBC) have replaced PAP test.

Material and Methods:

Cervical smear and corresponding cervical biopsy materials of 300 patients diagnosed between 2014 January and 2016 September in Şişli Hamidiye Etfal Training and Research hospital were studied retrospectively. Smears were prepared with liquid – based cytology         (LBC) test SurePath. Biopsy materials were stained with the hematoxylin eosin method. Slides were evaluated according to Bethesda 2001 classification. Biopsy materials were classified into 4 categories according to WHO classification.

Results: Cytology results of 273 patients (91%) were abnormal. Biopsy results showed lesions such as low grade cervical intraepithelial lesion, high grade cervical intraepithelial lesion and squamous cell carcinoma in 178 patients (59.3%). The calculated sensitivity and specificity for LBC were 89.89% and 7.38%, indicating low accuracy of specificity for LBC.

Discussion: The management of treatment in diagnosis of epithelial cell abnormality in cervical cytology should be according to the sets of specified protocols. We may encounter HSIL in the biopsy with the diagnosis of atypical squamous cells of undetermined significance (ASCUS) in cytology. It can be better for the gynecologist managing of this group with colposcopy.



Keywords : 2001 Bethesda system, cervical cancer, liquid-based cytology (LBC,

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How to Cite :
Seyhan Ozakkoyunlu hascicek, Tuba Oğuzsoy, Kamile Gulcin Eken, Fevziye Kabukcuoglu, Comparison of liquid based cytology cervical smears with histopathological findings , J Clin Anal Med 2018;9.(5):359-362