About Us Online First Current Issue All Issues For Authors Search
Abstract

Prognostic value of soluble factors of angiogenesis and adhesion processes in head and neck squamous


PDF
Authors
Taylan GŁn, Aykut Ikinciogullari, Osman Fatih Boztepe, Serdar Ensari, Haci Huseyin Dere

J Clin Anal Med 2018;9(5):421-424
doi:10.4328/JCAM.5788

Abstract

Aim: In this study, we aimed to define the prognostic value of two factors related to angiogenesis and adhesion processes of head and neck squamous cell carcinomas. The prominent angiogenesis molecule is vascular endothelial growth factor (VEGF). Vascular cell adhesion molecule (VCAM) first attracted attention more than two decades ago as endothelial adhesion receptor with key function for leukocyte recruitment in term of cellular immune response. Material and method: 35 patients with head and neck squamous cell carcinomas were enrolled in this study. Control group consisted of 20 people who have no sign of regional or systemic diseases. 33 patients were male and 2 patients were female. Mean age was 59.7 years (28-76). Results: We showed that VEGF levels in the patient group was significantly higher than the control group (p=0,001). However, when comparing the VEGF levels of different stages, there was no statistical significant difference between the stages. Discussion: Serum VEGF levels can provide sufficient information for the early diagnosis of the disease but prognosis may not be evaluated according to the results of our study. VCAM levels were not specific and sensitive to use as a tumor marker but it may be a valuable factor to determine the prognosis and tumor aggression in cancer patients.



Keywords : Vascular cell adhesion molecule, vascular endothelial growth factor, prognosis,

Citations in Google Scholar

How to Cite :
Taylan GŁn, Aykut Ikinciogullari, Osman Fatih Boztepe, Serdar Ensari, Haci Huseyin Dere, Prognostic value of soluble factors of angiogenesis and adhesion processes in head and neck squamous, J Clin Anal Med 2018;9.(5):421-424