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Abstract

Factors affecting response rates after thymectomy for myasthenia gravis: results of surgery


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Authors
Fazli Yanik, Yekta Altemur Karamustafaoglu, Yener Yoruk

J Clin Anal Med 2018;9(5):434-438
doi:10.4328/JCAM.5811

Abstract

Background: In our study, we have reported the clinical response obtained after transsternal extended thymectomy (TSET), the factors affecting the response and the most appropriate operation time.

Method: A total of 35 cases underwent TSET with the diagnosis of Myasthenia Gravis (MG) in our department between December 1996- June 2015. Twenty of the cases were females (57%) and fifteen (43%) were males with a mean age of 4215(14-68). Case registry have been analyzed retrospectively.

Results: Postoperative histopathological examination was revealed non-thymoma thymic pathologies in 19(54%), thymoma in 16(46%). Myasthenia Gravis symptoms were staged according to Osserman classification: 8(22.9%) were stage I, 13(37.1% ) were stage IIa, 11(31.4% ) were stage IIb ve 3(8.6%) were stage III and we had no patient at stage IV. Symptoms duration before operation < 24 month were statistically significant for groups with and without tymoma (p < 0.001). However, parameters as age, gender, preoperative Osserman stage and pathological diagnosis were not statistically significant.

Conclusion: Transsternal extended thymectomy allows an extended removal of all the mediastinal tissue in the anterior mediastinum with minimum complication rate. Symptom duration before operation is most important factor in response to treatment therefore, patients must be operated as soon as early. Thymectomy seems to be helpful also for early stage MG.

 



Keywords : Myasthenia, surgery, thymectomy,

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How to Cite :
Fazli Yanik, Yekta Altemur Karamustafaoglu, Yener Yoruk, Factors affecting response rates after thymectomy for myasthenia gravis: results of surgery , J Clin Anal Med 2018;9.(5):434-438